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Dolasetron Mesylate Monohydrate Solution for injection

What is this medicine?

DOLASETRON (dol A se tron) is used to treat and prevent nausea and vomiting after surgery.

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health-care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this medicine may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • chest tightness

  • dizziness

  • fast or irregular heartbeat

  • feeling faint or lightheaded, falls

  • fever and chills

  • swelling of the feet or hands

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea

  • headache

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • arsenic trioxide

  • certain antipsychotics like haloperidol, thioridazine, ziprasodone

  • certain medicines for chemotherapy like daunorubicin, epirubicin, idarubicin

  • certain medicines for irregular heart beat like amiodarone, disopyramide, dofetilide, ibutilide, procainamide, propafenone, quinidine, sotalol

  • certain medicines used for nausea like chlorpromazine, droperidol

  • certain medicines used to treat infections like chloroquine, clarithromycin, erythromycin, pentamidine

  • cisapride

  • dextromethorphan; quinidine

  • dronedarone

  • flecainide

  • methadone

This medicine may also interact with the following medications:

  • antiviral medicines for HIV or AIDS

  • atenolol

  • beta-blockers like propranolol

  • calcium channel blockers like diltiazem and verapamil

  • cimetidine

  • digoxin

  • diuretics

  • rifampin

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart disease

  • history of irregular heartbeat

  • kidney disease

  • low levels of magnesium or potassium in the blood

  • an unusual or allergic reaction to dolasetron, granisetron, ondansetron, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.