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Metolazone Oral tablet

What is this medicine?

METOLAZONE (me TOLE a zone) is a diuretic. It increases the amount of urine passed, which causes the body to lose salt and water. This medicine is used to treat high blood pressure. It is also reduces the swelling and water retention caused by heart or kidney disease.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Remember that you will need to pass urine frequently after taking this medicine. Do not take your doses at a time of day that will cause you problems. Do not take at bedtime. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions such as skin rash or itching, hives, swelling of the lips, mouth, tongue, or throat

  • fast or irregular heartbeat, chest pain

  • feeling faint

  • fever, chills

  • gout pain

  • hot red lump on leg

  • muscle pain, cramps

  • nausea, vomiting

  • numbness or tingling in hands, feet

  • pain or difficulty when passing urine

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • unusual bleeding or bruising

  • unusually weak or tired

  • yellowing of the eyes, skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • abdominal pain

  • blurred vision

  • constipation or diarrhea

  • dry mouth

  • headache

What may interact with this medicine?

  • alcohol

  • antiinflammatory drugs for pain or swelling

  • barbiturates for sleep or seizure control

  • digoxin

  • dofetilide

  • lithium

  • medicines for blood sugar

  • medicines for high blood pressure

  • medicines that relax muscles for surgery

  • methenamine

  • other diuretics

  • some medicines for pain

  • steroid hormones like cortisone, hydrocortisone, and prednisone

  • warfarin

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • diabetes

  • gout

  • immune system problems, like lupus

  • kidney disease

  • liver disease

  • pancreatitis

  • small amount of urine or difficulty passing urine

  • an unusual or allergic reaction to metolazone, sulfa drugs, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.

You may need to be on a special diet while taking this medicine. Ask your doctor.

Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine may affect your blood sugar level. If you have diabetes, check with your doctor or health care professional before changing the dose of your diabetic medicine.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.