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Pramlintide Acetate Solution for injection

What is this medicine?

PRAMLINTIDE (PRAM lin tide) is a man-made form of a hormone normally found in the body. It is used to treat type 1 and type 2 diabetes in adults. This medicine works with insulin to control blood sugar.

How should I use this medicine?

This medicine is for injection under the skin. You will be taught how to prepare and give this medicine. Use exactly as directed. Do not mix this medicine with insulin in the same syringe. Take this medicine immediately before meals. Take your medicine at regular intervals. Do not take your medicine more often than directed.

Always check the appearance of this medicine before using it. Do not use it if it is cloudy or has solid particles in it.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • dizziness

  • symptoms of low or high blood sugar (ask your doctor for a list of these symptoms)

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • headache

  • increase or decrease in fatty tissue under the skin, through overuse of a particular injection site

  • irritation at site where injected

  • loss of appetite

  • nausea or vomiting

  • stomach pain

  • tired

What may interact with this medicine?

  • atropine

  • cisapride

  • erythromycin

  • medicines for depression, anxiety, or psychotic disturbances

  • medicines used to treat stomach problems

  • narcotic medicines for pain

  • other medicines for diabetes like acarbose, miglitol

  • tegaserod

Many medications may cause changes in blood sugar, these include:

  • alcohol containing beverages

  • aspirin and aspirin-like drugs

  • chloramphenicol

  • chromium

  • female hormones, such as estrogens or progestins, birth control pills

  • heart medicines

  • isoniazid

  • male hormones or anabolic steroids

  • medications for weight loss

  • medicines for allergies, asthma, cold, or cough

  • medicines for mental problems

  • medicines called MAO inhibitors - Nardil, Parnate, Marplan, Eldepryl

  • niacin

  • NSAIDS, such as ibuprofen

  • pentamidine

  • phenytoin

  • probenecid

  • quinolone antibiotics such as ciprofloxacin, levofloxacin, ofloxacin

  • some herbal dietary supplements

  • steroid medicines such as prednisone or cortisone

  • thyroid hormones

  • diuretics

Some medications can hide the warning symptoms of low blood sugar (hypoglycemia). You may need to monitor your blood sugar more closely if you are taking one of these medications. These include:

  • beta-blockers, often used for high blood pressure or heart problems (examples include atenolol, metoprolol, propranolol)

  • clonidine

  • guanethidine

  • reserpine

What if I miss a dose?

It is important not to miss a dose. Your health care professional or doctor should discuss a plan for missed doses with you. If you do miss a dose, follow their plan. Do not take double doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store unopened vials in the refrigerator between 2 to 8 degrees C (36 to 46 degrees F). Do not freeze. Throw away any unused medicine after the expiration date.

Store opened vials (vials currently in use) in the refrigerator or at room temperature at or below 25 degrees C (77 degrees F). Do not freeze. Keeping this medicine at room temperature decreases the amount of pain during injection. Throw away any opened vials of this medicine 28 days after opening.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • HbA1c above 9

  • low blood sugar episodes

  • problems checking blood sugar

  • problems taking diabetes medicine

  • stomach problems like gastroparesis

  • trouble being able to tell when blood sugar is low

  • an unusual or allergic reaction to pramlintide, metacresol, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor for regular checks on your progress. Learn how to check your blood glucose and urine ketone levels. Sometimes it is hard to tell the difference between low and high blood sugar (see side effects). Use a blood sugar measuring device, whenever possible, before you treat high or low blood sugar.

When first starting to use this medicine, you should check your blood sugar more often, especially before and after meals. This will help lower the chance of having very low blood sugars. Discuss with your health care professional or doctor the results of your blood sugar monitoring at least once a week until your blood sugars, dose of this medicine, and dose of insulin are stable.

Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets.

Try not to change the brand and type of syringe unless your health care professional or doctor tells you to. Use a syringe one time only.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.

Many nonprescription cough and cold products contain sugar or alcohol. These can affect diabetes control or can alter the results of tests used to monitor blood sugar. Avoid alcohol. Avoid products that contain alcohol or sugar.