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Protamine Sulfate Solution for injection

What is this medicine?

PROTAMINE (PROH tuh meen) is used to treat heparin overdose.

How should I use this medicine?

This medicine is for slow infusion into a vein. It is usually given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • chest pain or tightness

  • dizziness

  • feeling faint or lightheaded, falls

  • flushing or feeling of warmth

  • nausea, vomiting

  • unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • gum bleeding or nosebleeds

  • unusual tiredness

What may interact with this medicine?

  • heparin

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • an unusual or allergic reaction to protamine, fish, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.