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Repaglinide, Metformin Hydrochloride Oral tablet

What is this medicine?

METFORMIN; REPAGLINIDE (met FOR min; re PAG lin ide) is used to treat type 2 diabetes. Treatment is combined with diet and exercise. This medicine helps your body to use insulin better.

How should I use this medicine?

Take this medicine by mouth. Swallow it with a drink of water. Follow the directions on the prescription label. Take this medicine before meals. It should be taken no earlier than 30 minutes before meals. If a meal is skipped, skip the dose for that meal. Do not take more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Elderly patients over 65 years old may have a stronger reaction and need a smaller dose.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • confusion

  • dark urine

  • dizziness

  • fast heartbeat

  • feeling anxious

  • fever, chills, sore throat

  • general ill feeling or flu-like symptoms

  • increased hunger

  • muscle aches or pains

  • nausea, vomiting

  • right upper belly pain

  • shakiness

  • slow or irregular heartbeat

  • sweating

  • unusual bleeding or bruising

  • unusual stomach pain or discomfort

  • unusually tired or weak

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • headache

  • heartburn

  • stomach gas, upset

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • certain contrast medicines given before X-rays, CT scans, MRI, or other procedures

  • dofetilide

  • gatifloxacin

  • gemfibrozil

This medicine may also interact with the following medications:

  • cimetidine

  • clarithromycin

  • amiloride

  • digoxin

  • diuretics

  • female hormones, like estrogens or progestins and birth control pills

  • isoniazid

  • isophane insulin (NPH)

  • medicines for blood pressure, heart disease, irregular heart beat

  • medicines for fungal or yeast infections such as itraconazole, ketoconazole, miconazole

  • morphine

  • nicotinic acid

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

  • phenytoin

  • procainamide

  • quinidine

  • quinine

  • ranitidine

  • rifampin

  • simvastatin

  • steroid medicines like prednisone or cortisone

  • stimulant medicines for attention disorders, weight loss, or to stay awake

  • thyroid medicines

  • trimethoprim

  • vancomycin

What if I miss a dose?

If you miss a dose before a meal, skip that dose. If it is almost time for your next dose, take only that dose with the next scheduled meal as directed. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at temperatures less than 25 degrees C (77 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • anemia

  • frequently drink alcohol-containing beverages

  • become easily dehydrated

  • heart attack

  • heart failure that is treated with medications

  • kidney disease

  • liver disease

  • polycystic ovary syndrome

  • serious infection or injury

  • vomiting

  • an unusual or allergic reaction to metformin, repaglinide, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.

If you have low blood sugar, eat or drink something that has sugar. Make sure others know to get medical help quickly if you have serious symptoms of low blood sugar, like if you become unconscious or have a seizure.

If you need surgery or if you will need a procedure with contrast drugs, tell your doctor or health care professional that you are taking this medicine.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.