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Sorafenib tosylate Oral tablet

What is this medicine?

SORAFENIB (soe RAF e nib) is a chemotherapy drug. It is used to treat liver cancer and kidney cancer.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Take this medicine on an empty stomach, at least 1 hour before or 2 hours after meals. Do not take with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • chest pain

  • dizziness

  • fever or chills, sore throat

  • high blood pressure

  • pain, tingling, numbness in the hands or feet

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • swelling in a leg

  • unusual bleeding or bruising

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • dry skin

  • hair loss

  • loss of appetite

  • mouth sores

  • nausea

  • stomach pain

What may interact with this medicine?

  • aminoglutethimide

  • aspirin

  • bexarotene

  • carbamazepine

  • carboplatin

  • dexamethasone

  • docetaxel

  • doxorubicin

  • fluorouracil

  • griseofulvin

  • irinotecan

  • medicines for seizures like oxcarbazepine, phenobarbital, phenytoin

  • medicines that treat blood clots like amediplase, streptokinase

  • medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin

  • modafinil

  • nafcillin

  • neomycin

  • paclitaxel

  • rifabutin

  • rifampicin

  • rifampin

  • some medicines for sleep like secobarbital

  • St. John's Wort

  • warfarin

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bleeding problems

  • infection (especially a virus infection such as chickenpox, cold sores, or herpes)

  • heart disease

  • high blood pressure

  • kidney disease

  • liver disease

  • lung cancer

  • an unusual or allergic reaction to sorafenib, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor for regular check ups. You will need to have blood work while you are taking this medicine.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Men and women should use effective birth control while taking this medicine and for 2 weeks after stopping this medicine. Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine.