What is this medicine?
TOLBUTAMIDE (tole BYOO ta mide) helps to treat type 2 diabetes. Treatment is combined with diet and exercise. This drug helps your body to use insulin better.
How should I use this medicine?
Take this medicine by mouth. Swallow with a drink of water. Follow the directions on the prescription label. Take your medicine at the same time each day. Do not take more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Elderly patients over 65 years old may have a stronger reaction and need a smaller dose.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
dark yellow or brown urine or yellowing of the eyes or skin
fever, chills, sore throat
low blood sugar (ask your doctor or healthcare professional for a list of these symptoms)
severe skin rash, redness, swelling or itching
unusual bleeding or bruising
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
What may interact with this medicine?
Many medications may cause an increase or decrease in blood sugar, these include:
alcohol containing beverages
aspirin and aspirin-like drugs
female hormones, like estrogens or progestins and birth control pills
male hormones or anabolic steroids
medicines for weight loss
medicines for allergies, asthma, cold, or cough
medicines for mental problems
medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
quinolone antibiotics like ciprofloxacin, levofloxacin, ofloxacin
some herbal dietary supplements
steroid medicines like prednisone or cortisone
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
glucose-6-phosphate dehydrogenase deficiency
severe infection or injury
an unusual or allergic reaction to tolbutamide, sulfa drugs, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. Learn how to check your blood sugar. Tell your doctor or health care professional if your blood sugar is high, you might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine. Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. If you have symptoms of low blood sugar, eat or drink something containing sugar at once and contact your doctor or health care professional. Make sure family members know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, like seizures or unconsciousness. They must get medical help at once.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.